role of early treatment with cyclooxygenase inhibitors and praziquantel on bilharzial hepatic collagenosis in mice

In this work, the effect of praziquantel [PZ and acetyl salicylic acid [ASA]-a cyclooxygenase inhibitor had been tried individually and combined to study their effects on both serum and liver hydroxyproline [HP] as an indicator of liver fibrosis in bilharzial mice. PZ given early in the sixth week post infection, in two doses two weeks apart was found to reduce significantly both serum and liver HP. Histopathological changes of the liver indicted no fibrosis in the portal tracts with a strong immune reaction in the form of granulomas and kupffer cells as well as secondary follicles in the spleen. ASA in two different timing schedules [on early; third week post infection and another late; sixth week post infection] in three doses/week for two weeks, reduced significantly both serum and liver HP with more pronounced effects with the late course of ASA. This effect of ASA is possibly by its prostaglandin synthesis blocking effect. Histopathological changes with ASA showed mostly the hepatotoxic effect of salicylates with minimal fibrosis in the portal tract. When PZ was combined with ASA, and both were given on the sixth week post infection, the most significant reduction of both serum and liver HP was produced and the histopathological changes coincided properly with the biochemical changes, where the number and size of granulomas were the least, with minimal damaging effect on hepatocytes

Efficacy of probucol in cases of hypertriglyceridemia

It has been reported by some workers that probucol has no effect on triglyceride level, meanwhile other reported greater reduction in triglyceride level with familial hyperlipidemia, especially with apolipoprotein E4. In this trial, the effect of probucol [A hypocholesterolemic agent] on serum triglyceride was further examined. Thirty-two patients were included in this study; 24 of them showed reduction of triglyceride after 2 weeks treatment with 500 mg probucol twice daily from 347 mg/dL to 243 mg/dL [29.9%]. Diabetic patients [14 cases] showed less response on the same dose from 385.5 mg% to 298 mg% [22.6%]. Six patients showed reduction only after increasing the dose to 500 mg TDS for 4 weeks from 337 mg/dL to 303 mg/dL [10%]. Two patients did not show response and were switched to clofibrate. Probucol is effective in lowering triglyceride as well as cholesterol Levels

Synthesis of some peptides containing o-and p-amino methyl benzoate, aminobenzamide, phthalamide and therephthalamide residues

It is well established that several substituted o-and p-aminobenzoic acid and phthalamide derivatives have played an important role as nitrogen donor ligands in the synthesis of a wide variety of metal complexes. They also possess bacteriostatic, tuberculostatic and fungicidal activities. Recently, we have reported the synthesis of several N-tosylpeptide derivatives and some of which were found to be biologically active. As a continuation of this work the synthesis of some N-tosyldi-and tri-glycyl-o-[or-p-] amino methylbenzoate and the corresponding N, N'-bis derivatives of c-and p-aminobenzamide, phthalamide and terephtalamide derivatives [VII-XXII] and the study of their biological activities and copper [II] complexes are described in this note

Synthesis of 2-furylacryloylamino acids and dipeptide derivatives

Recently, a number of substituted furan-amino acid derivatives have been reported and found to possess different biological and pharmacological activities [1,2]. In continuation of our earlier work, the synthesis of some 2-furylacryloylamino acids, their methyl esters, hydrazides and dipeptide derivatives [II-XL1I] are reported